对映选择合成
立体中心
化学
多米诺骨牌
电泳剂
催化作用
手性(物理)
立体化学
组合化学
有机化学
手征对称性
物理
量子力学
夸克
Nambu–Jona Lasinio模型
作者
Shiyu Xu,Aima Huang,Yang Yang,Ying Wang,Ming Zhang,Zhenan Sun,Man Zhao,Yuanlin Wei,Guofeng Li,Hong Liu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-04-05
卷期号:24 (16): 2978-2982
被引量:12
标识
DOI:10.1021/acs.orglett.2c00845
摘要
The catalytic asymmetric synthesis of chiral compounds with multiple stereogenic elements via a single catalytic process is challenging. This paper proposes a domino asymmetric electrophilic halocyclization strategy for constructing heterocycloalkenyl atropisomeric spiroketal lactones. A single catalyst was utilized to realize two independent stereodetermining steps. Various spiroketal lactones containing both chiral axes and chiral centers were prepared in excellent yields with excellent enantioselectivity and diastereoselective (up to 99% ee and >20:1 dr).
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