基因
DNA微阵列
细胞周期
基因表达
生物
细胞周期蛋白依赖激酶1
计算生物学
遗传学
药物发现
基因表达谱
生物信息学
出处
期刊:Current Cancer Drug Targets
[Bentham Science]
日期:2001-05-01
卷期号:1 (1): 73-83
被引量:63
标识
DOI:10.2174/1568009013334241
摘要
Gene expression microarrays and gene expression databases provide new opportunities for the discovery of drug targets and for determination of a drug's mode of action. We review gene expression analysis methods and describe studies that have identified cell cycle genes using differential expression analysis and co-expression analysis. We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, topoisomerase II, and others.
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