氧化应激
脂质过氧化
六烯酸
花生四烯酸
体内
异丙醇
化学
活性氧
生物化学
药理学
抗氧化剂
生物
脂肪酸
多不饱和脂肪酸
生物技术
酶
出处
期刊:Biofactors
[Wiley]
日期:2008-01-01
卷期号:34 (2): 171-180
被引量:234
标识
DOI:10.1002/biof.5520340208
摘要
Abstract Oxidative stress induced by reactive oxygen and nitrogen species has been implicated in the pathogenesis of various disorders and diseases. Biomarkers are needed for assessment of oxidative stress status in vivo and also for health examination, diagnosis at early stage, prognosis, safe and efficient drug development, and evaluation of efficacy of drugs, foods, beverages, and supplements. Lipids are susceptible to oxidation and lipid peroxidation products are potential biomarkers for oxidative stress status in vivo and its related diseases. Recently, isoprostane, isoprostaglandin homologues from arachidonic acid, neuroprostanes from docosahexaenoic acid, hydroxyoctadecadienoic acid from linoleic acid, and oxysterols from cholesterol have received much attention as potential biomarkers for oxidative stress status in vivo . The physiological levels of these lipid peroxidation products and potential application as biomarkers will be reviewed.
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