Improved X-ray absorption capability of Core-shell nano-transducer in situ enhances γ-ray-excited radioluminescence imaging in vivo

This work presents a progressive optimization of lanthanide-based nanoparticles (LnNPs) scintillators, unveiling their structure-dependent radioluminescence properties for enhanced output efficiency. It thereby provides key insights into energy transfer processes within core-shell architectures and fundamentally expands the repertoire of applicable radionuclides for optical imaging.