ACG Clinical Guideline Update: Ulcerative Colitis in Adults

Ulcerative colitis is an idiopathic inflammatory disorder of unknown etiology that seems to be rising in incidence and prevalence throughout the world. These guidelines were developed to indicate the preferred approach to the management of adult patients with ulcerative colitis as established by valid scientific research and represent the official practice recommendations of the American College of Gastroenterology under the auspices of the Practice Parameters Committee. The scientific evidence for the recommendations made in these guidelines was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation process, assessing the quality of the evidence (high, moderate, low, or very low) and assigning a strength of recommendation based on its apparent clinical benefit (strong or conditional). In instances where the available evidence was not appropriate for a formal Grading of Recommendations Assessment, Development, and Evaluation recommendation, but there was consensus of significant clinical merit, statements were developed using expert consensus (termed key concept statements). These guidelines are meant to be broadly applicable to practitioners regardless of specialty or interest and should be viewed as the preferred, but not only, approach to clinical scenarios. As opposed to standards of care, guidelines are inherently flexible, and physicians should use them as tools in choosing the best course in a specific clinical situation. These guidelines represent the state of the evidence at the time of this publication. As new evidence emerges, these guidelines will be continuously reviewed, and updates will be published as needed to assure continued validity.