Gamma Knife radiosurgery in a cohort of neurofibromatosis type 2–associated and sporadic pediatric meningiomas and schwannomas

放射外科 医学 神经纤维瘤病 2型神经纤维瘤病 队列 伽玛刀 放射科 内科学 放射治疗
作者
Abhijit Goyal‐Honavar,Dwarakanath Srinivas,Subhas Konar,Manish Beniwal,Andiperumal Raj Prabhuraj,Arimappamagan Arivazhagan,K. V. L. Narasinga Rao,Sampath Somanna
出处
期刊:Journal of neurosurgery [Journal of Neurosurgery Publishing Group]
卷期号:: 1-7
标识
DOI:10.3171/2025.1.peds24308
摘要

OBJECTIVE Pediatric intracranial tumors present a unique spectrum of pathology and their own challenges. However, little data are available on the use of Gamma Knife radiosurgery (GKRS) in their management. Therefore, the authors aimed to present their experience with GKRS in treating pediatric tumors, focusing on the impact of associated neurofibromatosis (NF) on the outcomes. METHODS This retrospective review assimilated data of patients ≤ 18 years old who underwent GKRS between January 2013 and December 2021 for tumors. Outcomes were compared among tumors associated with NF and those that were not. RESULTS Twenty-six patients were treated for 40 tumors, with a mean patient age of 15.4 ± 1.7 years. Thirteen patients were diagnosed with NF type 2 (NF2). The most frequent tumor was schwannoma (75%), followed by meningioma (25%). The mean dose delivered was 12.8 ± 2.2 Gy. After a mean follow-up of 51 months, all tumors regressed or remained stable. Regression of tumor occurred significantly more frequently among non–NF2-associated meningiomas and schwannomas (11/11, 100%) compared with 20 (68.9%) of 29 NF2-associated meningiomas and schwannomas (p = 0.036), with a significantly greater decrease in tumor volume (21.7% [IQR 14.8%–62.1%] vs 10.5% [IQR 3.4%–14.6%]; p < 0.001). CONCLUSIONS GKRS appears to be effective in achieving tumor control in meningiomas and schwannomas in the pediatric population. Although tumor regression occurs less frequently in patients with NF2, outcomes are largely favorable, with a low rate of acute and delayed complications.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
传奇3应助zcg采纳,获得10
1秒前
孙家贝发布了新的文献求助10
2秒前
2秒前
华仔应助FC采纳,获得10
3秒前
yongziwu完成签到,获得积分10
5秒前
烟花应助AI_S采纳,获得10
7秒前
8秒前
阳光发布了新的文献求助10
8秒前
10秒前
生动谷南发布了新的文献求助10
10秒前
欣喜灯泡发布了新的文献求助10
12秒前
CipherSage应助孙家贝采纳,获得10
12秒前
科研通AI2S应助jingjun_Li采纳,获得10
13秒前
还在吗完成签到,获得积分10
13秒前
生命科学的第一推动力完成签到 ,获得积分10
14秒前
lzh发布了新的文献求助10
16秒前
feng1235完成签到,获得积分10
17秒前
打打应助欣喜灯泡采纳,获得10
20秒前
lzh完成签到,获得积分10
23秒前
自己完成签到,获得积分10
28秒前
29秒前
29秒前
30秒前
30秒前
30秒前
31秒前
js完成签到,获得积分10
31秒前
雪白鸿涛发布了新的文献求助10
33秒前
梧桐完成签到,获得积分10
33秒前
123发布了新的文献求助10
34秒前
Valley发布了新的文献求助10
34秒前
情怀应助123采纳,获得10
34秒前
TRY发布了新的文献求助10
35秒前
饱满以松完成签到 ,获得积分10
36秒前
得偿所愿完成签到 ,获得积分10
38秒前
十一苗完成签到 ,获得积分10
39秒前
feige完成签到 ,获得积分10
40秒前
40秒前
42秒前
leiiiiiiii完成签到,获得积分10
42秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Technologies supporting mass customization of apparel: A pilot project 450
Mixing the elements of mass customisation 360
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
the MD Anderson Surgical Oncology Manual, Seventh Edition 300
Nucleophilic substitution in azasydnone-modified dinitroanisoles 300
Political Ideologies Their Origins and Impact 13th Edition 260
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3781499
求助须知:如何正确求助?哪些是违规求助? 3327165
关于积分的说明 10229864
捐赠科研通 3042037
什么是DOI,文献DOI怎么找? 1669761
邀请新用户注册赠送积分活动 799278
科研通“疑难数据库(出版商)”最低求助积分说明 758757