The Cerebellum as the Central Hub of a Widespread Network in Essential Tremor

Essential tremor (ET) is the most common movement disorder affecting an estimated 0.5 percent of people worldwide and 5 percent of adults older than 65 years.1 While ET is defined as tremor in the upper extremities, many patients also have other neurologic signs and symptoms, including tremor in other body parts, other motor symptoms, mild cognitive impairment, and neuropsychiatric symptoms. The neural mechanisms leading to ET and its associated motor and nonmotor symptoms remain largely unknown, and there is an ongoing debate surrounding whether ET should be classified as a neurodegenerative disorder.