胃弯曲度
细胞外
胃窦
卡哈尔间质细胞
运动性
曲率
体内
胃窦
振幅
波前
幽门窦
化学
物理
生物物理学
解剖
胃
生物
光学
几何学
内分泌学
数学
细胞生物学
平滑肌
生物化学
生物技术
作者
Omkar N. Athavale,Madeleine R. Di Natale,Recep Avci,Alys R. Clark,John B. Furness,Leo K. Cheng,Peng Du
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology
[American Physiological Society]
日期:2024-06-11
卷期号:327 (2): G254-G266
被引量:2
标识
DOI:10.1152/ajpgi.00069.2024
摘要
Rhythmic electrical events, termed slow waves, govern the timing and amplitude of phasic contractions of the gastric musculature. Extracellular multielectrode measurement of gastric slow waves can be a biomarker for phenotypes of motility dysfunction. However, a gastric slow-wave conduction pathway for the rat, a common animal model, is unestablished. In this study, the validity of extracellular recording was demonstrated in vitro with simultaneous intracellular and extracellular recordings and by pharmacological inhibition of slow waves. The conduction pathway was determined by in vivo extracellular recordings while considering the effect of motion. Slow-wave characteristics [means (SD)] varied regionally having higher amplitude in the antrum than the distal corpus [1.03 (0.12) mV vs. 0.75 (0.31) mV;
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