肠-脑轴
亨廷顿病
疾病
肠道菌群
情感(语言学)
认知
神经科学
医学
心理学
免疫学
病理
沟通
作者
Chloe J. Love,Bethany A. Masson,Carolina Gubert,Anthony Hannan
出处
期刊:International Review of Neurobiology
日期:2022-01-01
卷期号:: 141-184
被引量:4
标识
DOI:10.1016/bs.irn.2022.06.005
摘要
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an autosomal dominant trinucleotide (CAG) tandem repeat, resulting in complex motor, psychiatric and cognitive symptoms as well as gastrointestinal disturbances and other peripheral symptoms. There are currently no disease-modifying treatments, and the peripheral pathology of the disorder is not well understood. Emerging evidence suggests that the bi-directional communication pathways between the gut and the brain, including the microbiota-gut-brain axis, can affect motor, psychiatric and cognitive symptoms as well as weight loss and sexual dimorphism seen in HD. Furthermore, both HD and the microbiota-gut-brain axis can be influenced by environmental factors, opening potential new avenues to explore therapeutic options for this devastating disorder.
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