化学
环丁酮
区域选择性
串联
肟
催化作用
级联反应
基质(水族馆)
组合化学
有机化学
脱质子化
药物化学
立体化学
戒指(化学)
离子
材料科学
海洋学
复合材料
地质学
作者
Panpan Wang,Yuting Leng,Yangjie Wu
标识
DOI:10.1002/ejoc.202201091
摘要
Abstract An effective strategy for construction of 1,5‐dihydro‐2H‐pyrrol‐2‐one scaffolds by a cascade of 1,5‐dienes with cyclobutanone oxime esters was developed. The reaction proceeded through radical addition, 5‐endo cyclization, and subsequent deprotonation, in which two new C−C bonds were formed. This protocol features excellent regioselectivity and a low‐cost catalyst, as well as broad substrate scope, which are expected to promote its potential applications in pharmacy and synthetic chemistry.
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