Copper(I)‐Catalyzed Regioselective Tandem Cyanoalkylative Cyclization of 1,5‐Dienes with Cyclobutanone Oxime Esters

Abstract An effective strategy for construction of 1,5‐dihydro‐2H‐pyrrol‐2‐one scaffolds by a cascade of 1,5‐dienes with cyclobutanone oxime esters was developed. The reaction proceeded through radical addition, 5‐endo cyclization, and subsequent deprotonation, in which two new C−C bonds were formed. This protocol features excellent regioselectivity and a low‐cost catalyst, as well as broad substrate scope, which are expected to promote its potential applications in pharmacy and synthetic chemistry.