癫痫
共病
兴奋毒性
注意缺陷多动障碍
联想(心理学)
神经科学
心理学
精神科
医学
NMDA受体
心理治疗师
内科学
受体
作者
Jay A. Salpekar,Gaurav Mishra
标识
DOI:10.1016/j.yebeh.2016.02.017
摘要
We read with great interest the letter of K. Fluegge in reply to our original paper, “Key issues in addressing the comorbidity of attention-deficit hyperactivity disorder and pediatric epilepsy” [ [1] Fluegge K. Does the association between ADHD and pediatric epilepsy signal a tolerance continuum to human environment exposure? A reply to Salpekar and Mishra (2014). Epilepsy Behav. 2016; (in press) PubMed Google Scholar ]. Fluegge acknowledges the high comorbidity of the two conditions and considers that environmental toxins, particularly air pollution, may play a “principal” role. The suggestion is made that nitrous oxide, a possible component of air pollution, albeit a commonly used anesthetic, may predispose the appearance of ADHD following traumatic brain injury. Further, the physiologic mechanism is implied to be similar to the excitotoxicity potentially found in anti-NMDA antibody-mediated encephalitis.
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