心理学
神经心理学
晚年抑郁症
情景记忆
穹窿
部分各向异性
胼胝体
执行职能
认知
听力学
神经科学
白质
磁共振成像
医学
海马体
放射科
作者
Claire E. Sexton,Lisa McDermott,Ukwuori G. Kalu,Lucie L. Herrmann,Kevin M. Bradley,Charlotte L. Allan,Marisa Le Masurier,Clare E. Mackay,Klaus P. Ebmeier
标识
DOI:10.1017/s0033291711002352
摘要
Neuropsychological impairment is a key feature of late-life depression, with deficits observed across multiple domains. However, it is unclear whether deficits in multiple domains represent relatively independent processes with specific neural correlates or whether they can be explained by cognitive deficits in executive function or processing speed.We examined group differences across five domains (episodic memory; executive function; language skills; processing speed; visuospatial skills) in a sample of 36 depressed participants and 25 control participants, all aged ≥ 60 years. The influence of executive function and processing speed deficits on other neuropsychological domains was also investigated. Magnetic resonance imaging correlates of executive function, processing speed and episodic memory were explored in the late-life depression group.Relative to controls, the late-life depression group performed significantly worse in the domains of executive function, processing speed, episodic memory and language skills. Impairments in executive function or processing speed were sufficient to explain differences in episodic memory and language skills. Executive function was correlated with anisotropy of the anterior thalamic radiation and uncinate fasciculus; processing speed was correlated with anisotropy of genu of the corpus callosum. Episodic memory was correlated with anisotropy of the anterior thalamic radiation, the genu and body of the corpus callosum and the fornix.Executive function and processing speed appear to represent important cognitive deficits in late-life depression, which contribute to deficits in other domains, and are related to reductions in anisotropy in frontal tracts.
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