神经科学
NMDA受体
磁刺激
心理学
神经可塑性
兴奋剂
运动皮层
运动学习
经颅直流电刺激
神经生理学
作者
Michael A. Nitsche,Wiebke Jaussi,David Liebetanz,Nicolas Lang,Frithjof Tergau,Walter Paulus
标识
DOI:10.1038/sj.npp.1300517
摘要
D-Cycloserine (CYC), a partial N-methyl-D-aspartate (NMDA) agonist, has been shown to improve cognitive functions in humans. However, the neurophysiological basis of this effect is unclear so far. We studied the impact of this drug on long-lasting after-effects of transcranial direct current (tDCS)-generated motor cortical excitability shifts, as revealed by transcranial magnetic stimulation-elicited motor-evoked potentials. While anodal tDCS enhances motor cortical excitability, cathodal tDCS diminishes it. Both effects seem to be NMDA receptor dependent. D-CYC selectively potentiated the duration of motor cortical excitability enhancements induced by anodal tDCS. D-CYC alone did not modulate excitability. The potency of this drug to consolidate neuronal excitability enhancements, most probably by stabilizing the strengthening of NMDA receptors, which is a probable neurophysiological derivate of learning processes, makes it an interesting substance to improve cognitive functions.
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