硼酸化
化学
硼酸
芳基
钯
铃木反应
催化作用
组合化学
卤化物
偶联反应
有机化学
烷基
作者
Gary A. Molander,Sarah L. J. Trice,Steven M. Kennedy
摘要
The use of bis-boronic acid for the direct synthesis of boronic acids has greatly facilitated the two-step, one-pot borylation/Suzuki cross-coupling reaction between aryl and heteroaryl halides. With use of Buchwald's second-generation XPhos preformed catalyst, high yields of cross-coupled products were obtained for most substrates. The method also allows an efficient two-step, one-pot synthesis, providing access to three distinct cross-coupled products after column chromatography. The method also provides a rapid and convenient route to teraryl compounds.
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