奥美沙坦
同源建模
同源(生物学)
血管紧张素II
计算生物学
生物信息学
对接(动物)
化学
受体
生物信息学
生物
生物化学
基因
医学
内分泌学
护理部
酶
血压
出处
期刊:Methods in molecular biology
日期:2018-01-01
卷期号:: 449-460
被引量:1
标识
DOI:10.1007/978-1-4939-8630-9_27
摘要
For many years structural studies of the angiotensin II type 1 receptor (AT1R) solely relied on mutagenesis experiments combined with homology modeling. The recent publication of the co-crystallized structures of AT1R with the antagonists ZD7155 and olmesartan allows comparative studies. In this chapter the binding modes of olmesartan in the crystal structures and the homology models are compared utilizing mutagenesis data. The obtained results suggest that both homology and crystal structures should be used for future rational drug design. Of paramount importance are these co-crystallized structures or homology models to be simulated in a lipid bilayer environment that mimics the biological.
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