电场
微生物
领域(数学)
分子生物物理学
材料科学
工程物理
纳米技术
物理
生物系统
凝聚态物理
生物
遗传学
数学
细菌
量子力学
核磁共振
纯数学
作者
Ayman H. El-Hag,Shesha Jayaram,Oscar Rodriguez Gonzalez,Mansel W. Griffiths
出处
期刊:IEEE Transactions on Nanobioscience
[Institute of Electrical and Electronics Engineers]
日期:2011-09-01
卷期号:10 (3): 133-138
被引量:31
标识
DOI:10.1109/tnb.2011.2163078
摘要
In this paper the effect of microorganism size and shape on the killing efficiency of pulsed electric field (PEF) is investigated both experimentally and using a transient finite element program. The effect of cell size, membrane thickness, cell shape (spherical, elliptical, and cylindrical) on the calculated transmembrane voltage is studied. It has been found that both the cell size and cell membrane thickness have significant effect on the induced field across the cell membrane. The findings of the simulation results have been evaluated by comparing the trends with some experimental results. Five different types of microorganisms that have different shapes and dimensions have been inoculated with water at a conductivity level of 100 μS/cm and have been treated with the application of a pulsed electric field of 70 kV/cm. Significant difference in bacteria reduction was noticed between the treated cells which could be attributed to the cell size and shape.
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