γ-氨基丁酸受体
受体
药理学
神经科学
反激动剂
γ-氨基丁酸受体
GABA受体
镇静剂
γ-氨基丁酸
加巴能
荷包牡丹碱
兴奋剂
γ-氨基丁酸受体
化学
麝香醇
医学
生物
苯二氮卓
内科学
作者
Uwe Rudolph,Hanns Möhler
标识
DOI:10.1016/j.coph.2005.10.003
摘要
It is increasingly being appreciated that GABAA receptor subtypes, through their specific regional, cellular and subcellular localization, are linked to distinct neuronal circuits and consequently serve distinct functions. GABAA receptor subtype-selective drugs are therefore expected to provide novel pharmacological profiles. Receptors containing the alpha1 subunit mediate sedation and serve as targets for sedative hypnotics. Agonists selective for alpha2- and/or alpha3-containing GABAA receptors have been shown to provide anxiolysis without sedation in preclinical models, whereas inverse agonists selective for alpha5-containing GABAA receptors provide memory enhancement. Agonists selective for alpha3-containing GABAA receptors might be suitable for the treatment of deficits in sensorimotor processing in psychiatric disorders. Thus, a new pharmacology based on GABAA receptor subtype-specific actions is emerging.
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