Lessons from Domestication: Targeting Cis-Regulatory Elements for Crop Improvement

DOI of original article: https://doi.org/10.1016/j.tplants.2016.01.014 (Trends in Plant Science 21, 506–515, 2016) In this Review article, the final sentence in the Acknowledgments was incorrect. The corrected sentence is below: ‘This research was supported by funding from the Research Foundation Flanders (FWO) through the projects G005312N and G004515N and a postdoctoral fellowship to L.P.’ The authors apologize for the error. Lessons from Domestication: Targeting Cis-Regulatory Elements for Crop ImprovementSwinnen et al.Trends in Plant ScienceFebruary 11, 2016In BriefDomestication of wild plant species has provided us with crops that serve our human nutritional needs. Advanced DNA sequencing has propelled the unveiling of underlying genetic changes associated with domestication. Interestingly, many changes reside in cis-regulatory elements (CREs) that control the expression of an unmodified coding sequence. Sequence variation in CREs can impact gene expression levels, but also developmental timing and tissue specificity of expression. When genes are involved in multiple pathways or active in several organs and developmental stages CRE modifications are favored in contrast to mutations in coding regions, due to the lack of detrimental pleiotropic effects. Full-Text PDF