自噬
细胞凋亡
细胞生物学
程序性细胞死亡
串扰
生物
细胞应激反应
细胞
战斗或逃跑反应
遗传学
基因
物理
光学
作者
Maria Chiara Maiuri,Einat Zalckvar,Adi Kimchi,Guido Kroemer
摘要
The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is complex in the sense that, under certain circumstances, autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway. Autophagy and apoptosis may be triggered by common upstream signals, and sometimes this results in combined autophagy and apoptosis; in other instances, the cell switches between the two responses in a mutually exclusive manner. On a molecular level, this means that the apoptotic and autophagic response machineries share common pathways that either link or polarize the cellular responses.
科研通智能强力驱动
Strongly Powered by AbleSci AI