细胞外
细胞外基质
透明质酸
细胞生物学
结缔组织
炎症
胚胎干细胞
化学
伤口愈合
细胞
生物
病理
解剖
免疫学
医学
生物化学
基因
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2004-07-01
卷期号:4 (7): 528-539
被引量:1853
摘要
Hyaluronan is an extracellular and cell-surface-associated polysaccharide that is traditionally regarded as a biological 'goo' that participates in lubricating joints or holding together gel-like connective tissues. Although these are common physiological roles of hyaluronan in adult organisms, hyaluronan also functions as a microenvironmental cue that co-regulates cell behaviour during embryonic development, healing processes, inflammation and tumour development. Recent work highlights a key role for interactions between hyaluronan and tumour cells in several aspects of malignancy and indicates the possibility of new therapeutic strategies.
科研通智能强力驱动
Strongly Powered by AbleSci AI