Kinetics of Isophorone Synthesis via Self‐Condensation of Supercritical Acetone

Abstract A kinetic study on isophorone synthesis via self‐condensation of supercritical acetone catalyzed by aqueous KOH in a tubular flow reactor was conducted. The intention was to improve the isophorone selectivity, with the main approach to reduce the by‐products higher‐boiling than isophorone. A higher isophorone selectivity was obtained with increased reaction temperature. The structures of main products were determined by gas chromatography‐mass spectrometry and nuclear magnetic resonance analysis. The key reaction pathways and a corresponding kinetic model were proposed. The fitted apparent activation energies indicated the reason of isophorone selectivity improvement in that high temperature favors reversion of reversible by‐products.