横截面
矢状面
核医学
冠状面
乳腺癌
放射治疗
剂量学
成像体模
蒙特卡罗方法
放射治疗计划
医学
材料科学
放射科
数学
癌症
统计
内科学
作者
Benjamin Kopchick,Huijun Xu,Yuxin Niu,S Becker,Xiangyun Qiu,C Yu
摘要
Purpose Studies on Lattice radiotherapy (LRT) for breast cancer have been largely lacking. This study investigates the dosimetric feasibility of using Gamma Pod, a stereotactic radiotherapy apparatus originally designed for breast SBRT, to deliver LRT to large, bulky breast tumor as a noninvasive treatment option. Methods The GammaPod‐based LRT was simulated using Geant4 Gate Monte Carlo software. The simulated GammaPod was equipped with 5 mm diameter non‐coplanar circular beams that span 28° latitudinally from 18° to 43° off the horizontal plane. Two degrees longitudinal intervals were used to simulate rotating sources. To simulate the treatments to different breast sizes, three water‐equivalent hemisphere volumes with diameters of 10, 15, and 20 cm were analyzed. The lattice was planned by spacing focal points 2 cm apart in the transverse and sagittal planes and 2.5 cm in the coronal plane. This resulted in 22‐172 shots for full breast treatment. The maximum dose for each individual shot was 20 Gy. The peak‐to‐valley dose differences and skin dose were analyzed. To verify the feasibility of delivering LRT, a test plan was created and delivered to a commercial diode array dose verification device using a clinical GammaPod system with 15 mm collimators. Results The dose profiles showed the average peak‐to‐valley dose percent differences of 94.10% in the 10 cm hemispherical volume, 88.95% in the 15 cm hemispherical volume, and 83.60% in the 20 cm hemispherical volume. Average skin dose was 1.27, 1.72, and 2.13 Gy for the 10, 15, and 20 cm irradiation volumes, respectively. The LRT plan delivered using a clinical GammaPod system with larger collimators verified the feasibility of LRT plan delivery. Conclusion GammaPod‐based lattice radiotherapy is a viable treatment option and its application can be extended to treating large bulky breast tumors.
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