流行病学
医学
原发性血小板增多症
真性红细胞增多症
髓系白血病
骨髓纤维化
骨髓增生性疾病
入射(几何)
病因学
人口
内科学
免疫学
肿瘤科
骨髓
环境卫生
物理
光学
作者
Rory M. Shallis,Rong Wang,Amy J. Davidoff,Xiaomei Ma,Nikolai A. Podoltsev
出处
期刊:Blood Reviews
[Elsevier]
日期:2020-07-01
卷期号:42: 100706-100706
被引量:56
标识
DOI:10.1016/j.blre.2020.100706
摘要
The classical myeloproliferative neoplasms (MPNs), specifically chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF), represent clonal myeloid disorders whose pathogenesis is driven by well-defined molecular abnormalities. In this comprehensive review, we summarize the epidemiological literature and present our own analysis of the most recent the Surveillance, Epidemiology, and End Results (SEER) program data through 2016. Older age and male gender are known risk factors for MPNs, but the potential etiological role of other variables is less established. The incidences of CML, PV, and ET are relatively similar at 1.0–2.0 per 100,000 person-years in the United States, while PMF is rarer with an incidence of 0.3 per 100,000 person-years. The availability of tyrosine kinase inhibitor therapy has dramatically improved CML patient outcomes and yield a life expectancy similar to the general population. Patients with PV or ET have better survival than PMF patients.
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