Wnt信号通路
生物
癌症研究
癌变
转移
基因敲除
胆囊癌
癌症干细胞
胆囊
长非编码RNA
下调和上调
癌
连环素
干细胞
癌症
信号转导
细胞培养
基因
内科学
细胞生物学
医学
遗传学
作者
Chi-Ming Liang,Pinghua Yang,Tao Han,Ruo–Yu Wang,Xianglei Xing,Anfeng Si,Qian-Yun Ma,Zhong Chen,Hengyu Li,Baohua Zhang
出处
期刊:Gene
[Elsevier]
日期:2019-04-01
卷期号:694: 102-110
被引量:15
标识
DOI:10.1016/j.gene.2018.12.086
摘要
Increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) contribute to tumorigenesis, progression and recurrence of various malignancies including Gallbladder carcinoma (GBC). Lnc-DILC is reported to be the tumor suppressor gene to play an important role in liver cancer stem cells (CSCs). However, the role of lnc-DILC in GBC remains to be elucidated. Herein, we show that lnc-DILC is upregulated in gallbladder CSCs and GBC patients' tissues. Knockdown of lnc-DILC attenuates the self-renewal, tumorigenicity, proliferation and metastasis of gallbladder CSCs. Mechanistically, lnc-DILC promotes gallbladder CSCs expansion via Wnt/β-catenin pathway. Special Wnt/β-catenin inhibitor FH535 diminishes the discrepancy of self-renewal, growth and metastasis between lnc-DILC interference GBC cells and their control cells. In conclusion, lnc-DILC drives gallbladder CSCs self-renewal, tumorigenicity, proliferation and metastasis by activating Wnt/β-catenin signaling, and may therefore prove to be a potential therapeutic target for GBC patients.
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