纳米载体
纳米笼
细胞内
材料科学
缺氧(环境)
内化
纳米技术
生物物理学
纳米颗粒
肿瘤缺氧
癌症研究
细胞
氧气
化学
医学
生物化学
放射治疗
生物
有机化学
内科学
催化作用
作者
Jun Zhou,Chencheng Xue,Yanhua Hou,Menghuan Li,Yan Hu,Qiufang Chen,Yanan Li,Ké Li,Guanbin Song,Kaiyong Cai,Zhong Luo
出处
期刊:Biomaterials
[Elsevier]
日期:2019-03-01
卷期号:197: 129-145
被引量:43
标识
DOI:10.1016/j.biomaterials.2019.01.002
摘要
Hypoxia plays vital roles in the development of tumor resistance against typical anticancer therapies and local reoxygenation has proved effective to overcome the hypoxia-induced chemoresistance. Perfluorocarbon (PFC) is an FDA approved oxygen carrier and currently vigorously investigated for oxygen delivery to tumors. This study reports a perfluorocarbon and etoposide (EP) loaded porous hollow Fe3O4-based theranostic nanoplatform capable of delivering oxygen to solid tumors to enhance their susceptibility against EP. Results show that oxygen could be released at a moderate rate from the porous hollow magnetic Fe3O4 nanoparticles (PHMNPs) over an extended period of time, therefore effectively reducing the hypoxia-induced EP resistance of tumor cells. Moreover, the surface of PHMNPs was modified with lactobionic acid (LA)-containing amphiphilic polymers via hydrophobic interaction, which could provide targeting effect against certain types of tumors. The hydrophilic moiety would be subsequently shed by the intratumoral GSH after cellular internalization and result in the agglomeration of nanocarriers inside tumor cells, consequently impeding the nanoparticle exocytosis to enhance their intracellular retention. The enhanced retention could elevate the intracellular EP level and effectively boost the tumor cell killing effect. In addition to the therapeutic benefits, the Fe3O4 nanocage could also be used for the magnetic resonance imaging of the tumor area. The assorted benefits of the composite nanosystem are anticipated to be advantageous for the treatment of drug-resistant hypoxic tumors.
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