Hypervalent Iodine Chemistry as a Platform for Aerobic Oxidation Catalysis

Here, we highlight the recent development of aerobic oxidation catalysis via hypervalent I(III) and I(V) intermediates. The described chemistry intercepts reactive intermediates generated during aldehyde autoxidation to accomplish the oxidation of aryl iodides. The aerobically generated hypervalent iodine intermediates are utilized to couple an array of substrate functionalization chemistry to the reduction of O2. 1 Introduction 2 Chemistry of Aerobically Generated I(III) Intermediates 3 Chemistry of Aerobically Generated I(V) Intermediates 4 Conclusions