医学
糖尿病
多囊卵巢
入射(几何)
危险系数
血糖性
产科
内科学
内分泌学
胰岛素抵抗
置信区间
物理
光学
作者
Noel Ng,Hongjiang Wu,Eric S.H. Lau,Xinge Zhang,Aimin Yang,Atta Y.T. Tsang,Tsz Kok Yau,Alice Pik‐Shan Kong,K. Y. Ng,Jacqueline Pui Wah Chung,Elaine Chow,Juliana C.N. Chan,Lai Ping Cheung,Andrea Luk,Rong Ma
标识
DOI:10.1016/j.diabres.2023.110640
摘要
To ascertain the risk of progression to diabetes among Chinese women with PCOS.Women with PCOS (n = 3978) were identified from the Hong Kong Diabetes Surveillance Database based on the ICD-9 code for PCOS diagnosis and women without PCOS served as controls (n = 39780), matched 1:10 by age.The mean follow-up was 6.28 ± 4.20 and 6.95 ± 4.33 years in women with PCOS and controls, respectively. The crude incidence rate of diabetes was 14.25/1000 person-years in women with PCOS compared with 3.45 in controls. The crude hazard ratio of diabetes in women with PCOS was 4.23 (95 % CI: 3.73-4.80, p < 0.001). Further stratified by age group, the risk of developing diabetes decreased with increasing age but it remained significantly higher in women with PCOS across all age groups. It also suggested that the incidence rate of diabetes in women with PCOS aged 20-29 is highly comparable to that in healthy women aged ≥ 40. More than half of the incident diabetes captured during the follow-up in women with PCOS cohort were young-onset diabetes.Women diagnosed with PCOS at a younger age have the highest relative risk of developing diabetes, suggesting frequent glycemic status screening is required to detect diabetes at an early stage.
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