Multienzymatic Hybrid Metalloenzymes Triggering Cascade Reactions-Regulated Tumor Redox Homeostasis and Immunosuppressive Microenvironment for Catalytic Immunotherapy

@LOx/HA is the first multienzyme nanoplatform that can simultaneously modulate multiple redox homeostasis and the immunosuppressive TME for precise and efficient tumor catalytic immunotherapy. This biomimetic metalloenzyme strategy will inspire more innovative designs of multienzyme nanoplatforms for ROS-mediated tumor therapies.