MP23-05 PLATELET-RICH PLASMA INJECTION FOR THE TREATMENT OF STRESS URINARY INCONTINENCE IN FEMALES: A RANDOMIZED PLACEBO-CONTROLLED TRIAL

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Female Incontinence (MP23)1 May 2024MP23-05 PLATELET-RICH PLASMA INJECTION FOR THE TREATMENT OF STRESS URINARY INCONTINENCE IN FEMALES: A RANDOMIZED PLACEBO-CONTROLLED TRIAL Leah Ashton, Hannah Nataksuka, Colin Johnson, Kimberly Kenne, Karl Kreder, Ryan Kruse, Patrick Ten Eyck, Elizabeth Takacs, and Annah Vollstedt Leah AshtonLeah Ashton , Hannah NataksukaHannah Nataksuka , Colin JohnsonColin Johnson , Kimberly KenneKimberly Kenne , Karl KrederKarl Kreder , Ryan KruseRyan Kruse , Patrick Ten EyckPatrick Ten Eyck , Elizabeth TakacsElizabeth Takacs , and Annah VollstedtAnnah Vollstedt View All Author Informationhttps://doi.org/10.1097/01.JU.0001008776.99097.8a.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Platelet-rich plasma is an autologous solution with high concentrations of platelets and growth factors used for various health conditions with emerging application towards stress urinary incontinence in females. The aim of our study was to prospectively evaluate the efficacy and safety of PRP injection into the anterior vaginal wall as a treatment for stress urinary incontinence. We hypothesized that anterior vaginal wall PRP injection will be safe procedure and will be associated with improvement in SUI compared to placebo. METHODS: This was a single-blinded randomized placebo-controlled clinical trial, approved by an Institutional Review Board at a single institution and registered with Clinicaltrials.gov. Patients with bothersome stress-predominant urinary incontinence, confirmed by cough stress test and surveys, were enrolled. Participants were injected with 5 mL of either platelet-rich plasma or sterile saline into the anterior vaginal wall. We defined treatment success as a patient having subjective improvement and a negative provocative stress test at a bladder volume of 300 mL. We defined "subjective improvement" as a patient report of "very much better" or "much better" on the Patient Global Impression of Improvement (PGI-I). Secondary outcomes were improvements in the Female Sexual Function Index (FSFI) scores, Incontinence-Quality of Life (I-QOL) scores, and Questionnaire for Urinary Incontinence Diagnosis (QUID), as well as the VAS for pain, VAS for injector difficulty, perception of monetary value, and adverse events (AE). RESULTS: Fifty patients were enrolled in the study and randomized to the PRP group (n=25) or the saline placebo group (n=25). There was no statistically significant difference in the primary outcome of treatment "success" between the placebo and treatment group at all timepoints. There was no statistical difference in treatment success between active treatment and placebo group nor was there a difference in secondary outcomes. The secondary outcomes showed analogous results to the primary outcomes as there were no meaningful differences between the two groups when surveyed via FSFI, I-QOL, or QUID at the 1- 3- or 6-month follow-up intervals. AEs were minor and rate of AE was similar between both groups. CONCLUSIONS: In this randomized placebo-controlled study, we were unable to demonstrate a difference in SUI treatment success between PRP and saline injections. At this time, there is insufficient evidence to offer a one-time PRP injection into the anterior vaginal wall for treatment of female SUI. Source of Funding: University of Iowa Department of Urology Intradepartmental Grant 2022 © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e383 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Leah Ashton More articles by this author Hannah Nataksuka More articles by this author Colin Johnson More articles by this author Kimberly Kenne More articles by this author Karl Kreder More articles by this author Ryan Kruse More articles by this author Patrick Ten Eyck More articles by this author Elizabeth Takacs More articles by this author Annah Vollstedt More articles by this author Expand All Advertisement PDF downloadLoading ...