安普克
内分泌学
内科学
小岛
化学
链脲佐菌素
糖尿病
药理学
生物
医学
生物化学
蛋白激酶A
酶
作者
Xin Wang,Xiu Weiye,Yongdian Han,Zhili Wang,Yong Luo,Yina Ma
标识
DOI:10.26599/fshw.2022.9250130
摘要
Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by a glycolipid metabolism disorder and islet β-cell dysfunction. SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob, an agricultural byproduct. The hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this study. SCP-80-I was found to significantly reduce blood glucose and lipid deposition levels in T2DM mice, as well as decrease serum leptin and increase adiponectin secretion. Interestingly, RT-PCR and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins, including AMPK, CPT1, and ACC in the liver and AMPK, Sirt1, PGC-1α, and UCP2 in the pancreas. To have a hypoglycemic effect, SCP-80-I regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/ACC/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1α and AMPK/Sirt1/UCP2 signaling pathways. These findings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.
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