MiR-451a-Enriched Small Extracellular Vesicles Derived from Mg2+-Activated DPSCs Induce Vascularized Bone Regeneration through the AKT/eNOS/NO Axis

-EVs has enhanced potential of inducing vascularized bone regeneration. The present study provides a cation-activated strategy to modulate the cargos and contents of MSC-derived sEVs, obtaining desirable vascular promotion and bone regeneration potential. Furthermore, the developed β-TCP-modified delivery scaffolds represent a promising strategy for efficient loading and slow-release delivery of sEVs for clinical translation.