氧化应激
活性氧
化学
细胞凋亡
再灌注损伤
药理学
炎症
缺血
生物化学
免疫学
医学
内科学
作者
Haoge Geng,Jiayu Chen,Kangsheng Tu,Hang Tuo,Qingsong Wu,Jinhui Guo,Qingwei Zhu,Zhe Zhang,Yujie Zhang,Dongsheng Huang,Mingzhen Zhang,Qiuran Xu
标识
DOI:10.1186/s12951-023-02234-1
摘要
Hepatic ischemia-reperfusion injury (HIRI) is a pathophysiological process during liver transplantation, characterized by insufficient oxygen supply and subsequent restoration of blood flow leading to an overproduction of reactive oxygen species (ROS), which in turn activates the inflammatory response and leads to cellular damage. Therefore, reducing excess ROS production in the hepatic microenvironment would provide an effective way to mitigate oxidative stress injury and apoptosis during HIRI. Nanozymes with outstanding free radical scavenging activities have aroused great interest and enthusiasm in oxidative stress treatment.
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