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Editorial| March 2024 Astrocytes: Dual Roles in Chronic Pain and Memory Formation Vivianne L. Tawfik, M.D., Ph.D. Vivianne L. Tawfik, M.D., Ph.D. 1Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Stanford, California. Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information This editorial accompanies the article on p. 538. Accepted for publication October 31, 2023. Address correspondence to Dr. Tawfik: Anesthesiology March 2024, Vol. 140, 358–360. https://doi.org/10.1097/ALN.0000000000004832 Connected Content Article: Impaired Lactate Release in Dorsal CA1 Astrocytes Contributed to Nociceptive Sensitization and Comorbid Memory Deficits in Rodents Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Search Site Citation Vivianne L. Tawfik; Astrocytes: Dual Roles in Chronic Pain and Memory Formation. Anesthesiology 2024; 140:358–360 doi: https://doi.org/10.1097/ALN.0000000000004832 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll PublicationsAnesthesiology Search Advanced Search Topics: astrocytes, chronic pain, memory Astrocytes are glial cells, abundant in the central nervous system, that form a highly interconnected and organized network of cells.1 They make simultaneous close contact with thousands of synapses, allowing them to rapidly respond to, and even orchestrate, neuronal activity in homeostatic and pathologic conditions.2 It is now clear, however, that the specific contribution of astrocytes is location- and context-specific. For example, in the spinal cord, astrocytes can become “activated” after pain-producing injuries and negatively contribute to increased neuronal excitability through the release of gliotransmitters such as adenosine triphosphate, D-serine, and L-lactate.3,4 These complex cells are also, however, key positive contributors to processes such as memory formation.5 Astrocytes in the CA1 region of the hippocampus release L-lactate, which is taken up by neurons and triggers a series of downstream synaptic structural changes requisite for long-term memory.6 In this issue, Han et al.7... You do not currently have access to this content.