Composite lipid-inflammatory indices and mortality risk in NHANES 2007–2016

This study aims to investigate the associations of atherogenic index of plasma (AIP), systemic immune-inflammatory index (SII), monocyte-to-high-density lipoprotein cholesterol ratio (MHR), and neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) with cardiovascular disease (CVD) mortality and all-cause mortality. Utilizing data from the National Health and Nutrition Examination Survey 2007–2016, Cox proportional hazards models were employed to evaluate the relationships between these biomarkers and mortality outcomes. Analysis of 11,188 participants based on Framingham Risk Scores revealed that higher AIP, SII, NHR, and MHR levels are significant risk factors for cardiovascular and all-cause mortality. These associations remained robust after adjusting for covariates including age, sex, race, smoking, and alcohol consumption. Similar trends were observed for all-cause mortality. AIP, SII, MHR, and NHR are associated with an increased risk of CVD and all-cause mortality, suggesting their potential utility as novel biomarkers for risk stratification in clinical practice.