医学
抗磷脂综合征
血栓形成
怀孕
败血症
免疫学
抗体
狼疮抗凝剂
重症监护医学
内科学
生物
遗传学
作者
Jecko Thachil,Emmanuel J. Favaloro,Giuseppe Lippi
出处
期刊:Seminars in Thrombosis and Hemostasis
[Georg Thieme Verlag KG]
日期:2023-07-28
标识
DOI:10.1055/s-0043-1771268
摘要
Antiphospholipid syndrome (APS) is a hypercoagulable state caused by antiphospholipid antibodies (aPL). APS clinically manifests with arterial or venous or microvascular thrombi and/or pregnancy complications. It is well-known that the development of aPL can be a transient phenomenon and thus the current diagnostic criterion for APS requires repeat laboratory testing several weeks apart before a definitive diagnosis is made. However, transient presence of aPL may also be pathogenic. In this article, we attempt to give historical and clinical evidence for the importance of these antibodies, even when transient, and call for further research into mechanisms by which these antibodies may promote thrombosis and pregnancy morbidities.
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