医学
鼻喷雾剂
生理盐水
鼻塞
鼻腔给药
鼻测压
鼻粘膜
鼻孔
双盲
麻醉
临床试验
鼻子
安慰剂
鼻腔
慢性鼻-鼻窦炎
内科学
临床研究
随机化
单盲板
外科
病理
药理学
作者
Desiderio Passali,Raffaele Fiorella,Antonella Camaioni,Gerardo Villari,E. Mora,Gc Passali,Fm Passali,Andrea Crisanti,Luisa Bellussi
出处
期刊:Clinica Terapeutica
日期:2007-03-01
卷期号:158 (2): 139-45
被引量:5
摘要
The aim of our study was to evaluate the efficacy of 30 days treatment with glucan solution nasal spray vs. saline in the treatment of signs and symptoms of chronic rhinosinusitis.100 patients affected by chronic rhinosinusitis were enrolled. At the beginning and at the end of the study were evaluated: nasal congestion, headache, rhinorrea, facial pain, rhinopharyngeal exudate, inferior turbinate hypertrophy; a complete instrumental analysis of nasal functions by Active Anterior Rhinomanometry, nasal Muco-Ciliary Transport time and scraping of nasal mucosa was also performed. The patients were randomized 1:1 for receiving intranasal saline or intranasal glucan solution spray. Treatment was administered as follows: 2 puffs/nostril 3 times a day for 30 days.The patients in therapy with the glucan solution showed a significant improvement concerning rhinorrea facial pain, intensity of headache, inferior turbinate hypertrophy, rhinopharyngeal exudates, inspiratory/expiratory nasal resistences, Muco-ciliary transport time, normalization of nasal mucosas and rhinocytogram; saline lavage didn't show this effects. Both treatment improved rhinorrea, instead both treatment didn't affect nasal congestion.According to the results of our multicentric double blind randomized study, we suggest the use of glucan solution nasal spray as an efficacious therapeutic tool in the management of nasal symptoms in patients affected by chronic rhinosinusitis.
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