放射增敏剂
放射治疗
乳腺癌
癌症研究
体内
前药
胶体金
材料科学
癌症
医学
纳米颗粒
纳米技术
药理学
内科学
生物
生物技术
作者
Hamed Nosrati,Farzad Seidi,Ali Hosseinmirzaei,Navid Mousazadeh,Ali Mohammadi,Mohammadreza Ghaffarlou,Hossein Danafar,João Conde,Ali Sharafi
标识
DOI:10.1002/adhm.202102321
摘要
An optimal radiosensitizer with improved tumor retention has an important effect on tumor radiation therapy. Herein, gold nanoparticles (Au NPs) and drug-containing, mPEG-conjugated CUR (mPEG-CUR), self-assembled NPs (mPEG-CUR@Au) are developed and evaluated as a drug carrier and radiosensitizer in a breast cancer mice model. As a result, cancer therapy efficacy is improved significantly by applying all-in-one NPs to achieve synchronous chemoradiotherapy, as evidenced by studies evaluating cell viability, proliferation, and ROS production. In vivo anticancer experiments show that the mPEG-CUR@Au system improves the radiation sensitivity of 4T1 mammary carcinoma and completely abrogates breast cancer.
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