生物
阿克曼西亚
基因型
拟杆菌
粪便
微生物群
失调
肠道菌群
乳酸菌
生理学
疣状疣
遗传学
基因
肠道微生物群
维生素
微生物学
免疫学
内分泌学
细菌
16S核糖体RNA
厚壁菌
作者
Jianming Xu,Jie-Ni Zhang,Bohui Sun,Qing Liu,Juan Ma,Qian Zhang,Yongxin Liu,Ning Chen,Feng Chen
标识
DOI:10.1016/j.jgg.2021.08.015
摘要
Multifactors have been reported to affect the gut microbiome, including genotype, age, diet, and nutrition. However, few reports have investigated the relative capacity of different factors to shape the gut microbiome in a single study. Our design used a genetic vitamin A-deficient mouse model, the Rbp4-/- mouse, feeding with the low vitamin A diets at different ages of initiation (4 or 7 weeks) for 28 days. Fecal samples were collected for bacterial profiling at seven time points after diet controlling. With Rbp4 depletion, Akkermansia decreased and Bacteroides increased, whereas Desulfovibrio, Barnesiella, Clostridium_XlVa, and Lactobacillus fluctuated. The bacterial community swiftly adjusted with the vitamin A-deficient diet administration and gradually changed (e.g., decrease of Barnesiella and increase of Desulfovibrio). Age exerted a relatively weaker but long-last influence. At an earlier age to feed a vitamin A-deficient diet, a higher microbial dysbiosis index will be valued. Of note, the shaping effects of diet and age on the bacterial community varied with the difference of genotype, which might indicate a greater role of genotype than diet and age in shaping the gut microbiome.
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