光动力疗法
光敏剂
免疫原性细胞死亡
材料科学
纳米医学
背向效应
癌症研究
免疫系统
药物输送
免疫疗法
纳米技术
纳米颗粒
医学
化学
免疫学
有机化学
作者
Qiong Bian,Lingling Huang,Yihua Xu,Ruxuan Wang,Ye Gu,Anran Yuan,Xiaolu Ma,Jingyi Hu,Yuefeng Rao,Dong Xu,Hangxiang Wang,Gao J
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-12-03
卷期号:15 (12): 19468-19479
被引量:50
标识
DOI:10.1021/acsnano.1c06225
摘要
Nanomedicine-based photodynamic therapy (PDT) for melanoma treatment has attracted great attention. However, the complex design of polymer nanoparticles and high doses of photosensitizers used in intravenous injections (for sufficient accumulation of drugs in tumor lesions) pose a huge challenge to the commercialization and further clinical application. Herein, we fabricated the carrier-free nanoassemblies of a chlorin e6 (L-Ce6 NAs)-integrated fast-dissolving microneedles patch (L-Ce6 MNs) enriching only about 3 μg of Ce6 in the needle tips via a facile fabrication method. The L-Ce6 MNs had sufficient mechanical strength to penetrate the skin and facilitated the transportation of L-Ce6 NAs to a depth of 200-500 μm under the skin, thereby achieving efficient and accurate drug delivery to tumor lesions. In a xenograft mouse melanoma model, the L-Ce6 MNs-based PDT with low dose of Ce6 (0.12 mg/kg) exerted efficient ablation of the primary lesions in situ through reactive oxygen species (ROS) generation. More importantly, a significant abscopal effect was also elicited by activating immunogenic cell death (ICD) and releasing danger-associated molecular patterns (DAMPs), which in turn promoted dendritic cells (DCs) maturation and the subsequent antigen presentation, thereby facilitating the T-cell-mediated immune response without synergetic immunotherapies. Collectively, our findings indicate the facile, controllable, and fast-dissolving microneedles patch with a low dose of photosensitizers presented great therapeutic potential for enhanced photoimmunotherapy.
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