Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts

were used after their full characterization by imaging and spectroscopic techniques. The piezoelectric behavior of both NMs was evaluated using piezoresponse force microscopy (PRFM). During in vitro studies, the piezoelectricity of the NMs was stimulated with ultrasound (US) exposure. The results showed that the NMs are not cytotoxic at the concentrations tested and the migration ability and calcium deposit formation of the cells treated with the NMs and upon US exposure were significantly increased. These results demonstrate that the hBNs have the potential to accelerate bone tissue regeneration and promote bone healing. These findings offer a promising avenue for developing new therapies for bone-related injuries and conditions requiring significant bone remodeling.