硅氢加成
化学
酰胺
催化作用
立体选择性
齿合度
铂金
配体(生物化学)
组合化学
有机化学
药物化学
生物化学
晶体结构
受体
作者
Qisheng Wu,Zisong Qi,Shi Yin,Aijun Lin,Shang Gao,Hequan Yao
标识
DOI:10.1002/anie.202305518
摘要
Hydrofunctionalization of alkynes is one of the most efficient ways to access axially chiral styrenes with open-chained olefins. While great advances have been achieved for 1-alkynylnaphthalen-2-ols and analogues, atroposelective hydrofunctionalization of unactivated internal alkynes lags. Herein we reported a platinum-catalyzed atroposelective hydrosilylation of unactivated internal alkynes for the first time. With monodentate TADDOL-derived phosphonite L1 used as a chiral ligand, various axially chiral styrenes were achieved in excellent enantioselectivities with high E-selectivities. Control experiments showed that the NH-arylamide groups have significant effects on both the yields and enantioselectivities and could act as directing groups. The potential utilities of the products were shown by the transformations of the amide motifs of the products.
科研通智能强力驱动
Strongly Powered by AbleSci AI