轴手性
催化作用
化学
轴对称性
动力学分辨率
对映体
组合化学
手性(物理)
表面改性
基质(水族馆)
对映选择合成
有机化学
手征对称性
物理
量子力学
海洋学
结构工程
物理化学
夸克
地质学
Nambu–Jona Lasinio模型
工程类
作者
Yingtao Wu,Xin Guan,Huaqiu Zhao,Mingrui Li,Tianlong Liang,Jiaqiong Sun,Guangfan Zheng,Qian Zhang
摘要
Axially chiral diaryl ethers bearing two potential axes find unique applications in bioactive molecules and catalysis. However, only very few catalytic methods have been developed to construct structurally diverse diaryl ethers. We herein describe an NHC-catalyzed atroposelective esterification of prochiral dialdehydes, leading to the construction of enantioenriched axially chiral diaryl ethers. Mechanistic studies indicate that the matched kinetic resolutions play an essential role in the challenging chiral induction of flexible dual-axial chirality by removing minor enantiomers via over-functionalization. This protocol features mild conditions, excellent enantioselectivity, broad substrate scope, and applicability to late-stage functionalization, and provides a modular platform for the synthesis of axially chiral diaryl ethers and their derivatives.
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