18294 Topical treatment with kiwi-derived yeast extract increases hyaluronic acid resulting in improved skin hydration and clinically perceived facial radiance

Background: Hyaluronic acid (HA) is a key molecule involved in maintaining skin structure and moisture, synthesized by hyaluronic acid synthase 2 enzyme (HAS2). However, HAS2 gene expression and activity decrease with age, resulting in declining HA levels, loss of skin radiance and decreased skin firmness. We investigated the effect of a topical Kiwi-derived Yeast Extract (KDYE) on HA and HAS.