Analysis of 23 cases of adverse drug reaction induced by Ligustrazine Hydrochloride for Injection

Objective To analyze the characteristics of ADR induced by Ligustrazine Hydrochloride for Injection so as to promote the rational use of the drugs.Methods 23 cases of ADR relate to Ligustrazine Hydrochloride for Injection from March 2012 to April 2013 in Lixia District were analyzed statistically from patients with normal circumstances,adverse reaction,clinical manifestation,drug use and other aspects.Results Most of the patients taking the drug were old people whose average age was 64.48.Most of the reports(n = 12) involved both of the skin system and its appendages,accounting for 27.27%.Large doses of drug increase significantly in adverse reactions(78.26%) than the manual regulation dosage(13.04%).These cases of several drugs were more likely to have much serious adverse reaction(57.14%) than those of single medication using(11.11%).Conclusion The ADR of Ligustrazine Hydrochloride for Injection was related to the pharmaceutical factors and using.What's more,age distribution accorded with the indications for the crowd of the drug.Enterprises and doctors should pay more.