归巢(生物学)
骨髓
间质细胞
间充质干细胞
祖细胞
肿瘤微环境
癌症研究
造血
癌变
生物
干细胞
癌细胞
细胞生物学
免疫学
癌症
肿瘤细胞
遗传学
生态学
作者
Pauline Hanns,Anna M. Paczulla,Michael Medinger,Martina Konantz,Claudia Lengerke
出处
期刊:Cell stress
[Shared Science Publishers OG]
日期:2019-07-08
卷期号:3 (7): 221-235
被引量:21
标识
DOI:10.15698/cst2019.07.192
摘要
High vascularization and locally secreted factors make the bone marrow (BM) microenvironment particularly hospitable for tumor cells and bones to a preferred metastatic site for disseminated cancer cells of different origins. Cancer cell homing and proliferation in the BM are amongst other regulated by complex interactions with BM niche cells (e.g. osteoblasts, endothelial cells and mesenchymal stromal cells (MSCs)), resident hematopoietic stem and progenitor cells (HSPCs) and pro-angiogenic cytokines leading to enhanced BM microvessel densities during malignant progression. Stress and catecholamine neurotransmitters released in response to activation of the sympathetic nervous system (SNS) reportedly modulate various BM cells and may thereby influence cancer progression. Here we review the role of catecholamines during tumorigenesis with particular focus on pro-tumorigenic effects mediated by the BM niche.
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