斯达
先天性淋巴细胞
生物
STAT蛋白
效应器
细胞生物学
获得性免疫系统
先天免疫系统
JAK-STAT信号通路
贾纳斯激酶
信号转导
转录因子
免疫学
免疫系统
车站3
遗传学
基因
酪氨酸激酶
作者
Helena Stabile,Gianluca Scarno,Cinzia Fionda,Angela Gismondi,Angela Santoni,Massimo Gadina,Giuseppe Sciumè
摘要
Immunity to pathogens is ensured through integration of early responses mediated by innate cells and late effector functions taking place after terminal differentiation of adaptive lymphocytes. In this context, innate lymphoid cells (ILCs) and adaptive T cells represent a clear example of how prototypical effector functions, including polarized expression of cytokines and/or cytotoxic activity, can occur with overlapping modalities but different timing. The ability of ILCs to provide early protection relies on their poised epigenetic state, which determines their propensity to quickly respond to cytokines and to activate specific patterns of signal-dependent transcription factors. Cytokines activating the Janus kinases (JAKs) and members of the signal transducer and activator of transcription (STAT) pathway are key regulators of lymphoid development and sustain the processes underlying T-cell activation and differentiation. The role of the JAK/STAT pathway has been recently extended to several aspects of ILC biology. Here, we discuss how JAK/STAT signals affect ILC development and effector functions in the context of immune responses, highlighting the molecular mechanisms involved in regulation of gene expression as well as the potential of targeting the JAK/STAT pathway in inflammatory pathologies.
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