生物
锌指
B细胞
抗体
分子生物学
细胞生物学
分泌物
细胞分化
转录因子
基因
免疫学
遗传学
生物化学
作者
C.Alexander Turner,David H. Mack,Mark M. Davis
出处
期刊:Cell
[Elsevier]
日期:1994-04-01
卷期号:77 (2): 297-306
被引量:724
标识
DOI:10.1016/0092-8674(94)90321-2
摘要
We describe a novel gene, Blimp-1 (for B lymphocyte-induced maturation protein), transcripts of which are rapidly induced during the differentiation of B lymphocytes into immunoglobulin secretory cells and whose expression is characteristic of late B and plasma cell lines. The 856 amino acid open reading frame contains five Krüppel-type zinc finger motifs and proline-rich and acidic regions similar to those of known transcription factors. Serological studies show an approximately 100 kd protein that localizes to the nucleus. Stable or transient transfection of Blimp-1 into B cell lymphoma lines leads to the expression of many of the phenotypic changes associated with B cell differentiation into an early plasma cell stage, including induction of J chain message and immunoglobulin secretion, up-regulation of Syndecan-1, and increased cell size and granularity. Thus, Blimp-1 appears to be a pleiotropic regulatory factor capable of at least partially driving the terminal differentiation of B cells.
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