Expression of pyrrothineN-acyltransferase activities inSaccharothrix algeriensisNRRL B-24137: new insights into dithiolopyrrolone antibiotic biosynthetic pathway

The antitumor and antibiotic properties of dithiolopyrrolones are related to their variable acyl groups. New insights into regulation of biosynthetic pathway, especially the step of pyrrothine acylation, could lead after further studies to yield improvement and to selective production of dithiolopyrrolones with new biological activities.