心理学
基因座(遗传学)
萧条(经济学)
肥胖
基因
遗传学
神经科学
计算生物学
生物
内分泌学
经济
宏观经济学
作者
Stefan R. Bornstein,A. Schuppenies,Ma-Li Wong,Júlio Licinio
标识
DOI:10.1038/sj.mp.4001873
摘要
Obesity and depression are serious public health problems and also constitute cardiovascular disease risk factors. Research organizations have called for efforts to explore the interrelationship between obesity and depression. A useful starting point is the fact that in both disorders there is dysregulation of stress systems. We review molecular and clinical evidence indicating that the mediators of the stress response are a key locus for gene–environment interactions in the shared biology of depression and obesity. Scientific milestones include translational paradigms such as mice knockouts, imaging and pharmacogenomic approaches that can identify new therapeutic strategies for those burdened by these two afflictions of contemporary civilization. Perspectives for the future are promising. Our ability to dissect the underpinnings of common and complex diseases with shared substrates will be greatly enhanced by the Genes and Environment Initiative, the emerging Large Scale Studies of Genes and Environment in Common Disease, and the UK Biobank Project.
科研通智能强力驱动
Strongly Powered by AbleSci AI