共价键
细胞穿透肽
高分子
化学
药物输送
生物物理学
纳米技术
肽
医学
鼻腔给药
药理学
组合化学
生物化学
材料科学
有机化学
生物
作者
Zhao Wang,Yingzhi Chen,Ergang Liu,Junbo Gong,Meong Cheol Shin,Yongzhuo Huang
出处
期刊:Protein and Peptide Letters
[Bentham Science]
日期:2014-08-07
卷期号:21 (11): 1129-1136
被引量:11
标识
DOI:10.2174/0929866521666140807121903
摘要
Macromolecular drugs (e.g., proteins and nucleic acids) are highly environmentally liable and unstable, and their administration is strictly limited to injection. Moreover, a vast majority of macromolecules are cell membrane- impermeable, and it is a critical issue to enhance the cellular uptake efficiency for improving the treatment outcomes. Cell-penetrating peptide (CPP)-assisted strategy is promising for effective macromolecular delivery. As a case in point, CPP-mediated protein delivery has been considered as a revolutionary breakthrough. With aid of CPP, virtually all pro- teins can become cell-permeable. Generally, CPP-protein delivery works in a covalent delivery pattern, by which CPP and its cargo are linked via covalent bond. Recently, noncovalent delivery has also attracted attention for its potential application for protein delivery. In the presented work, the noncovalent pattern was demonstrated for its feasibi lity in percutaneous and nose-to-brain delivery with TAT/GFP as model drug, in comparison with the covalent method. Noncovalent CPP/protein delivery and its noninvasive application may provide a facile method for protein therapy. Keywords: Cell-penetrating peptide, noncovalent, nose-to-brain delivery, percutaneous delivery, protein delivery, TAT.
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